Affiliation:
1. McGill University 1 Department of Biology , , Montreal, Quebec, H3A 1B1 , Canada
2. Dalhousie University 2 Department of Biology , , Halifax, Nova Scotia , B3H 4R2, Canada
Abstract
ABSTRACT
Myofibrils are the intracellular structures formed by actin and myosin filaments. They are paracrystalline contractile cables with unusually well-defined dimensions. The sliding of actin past myosin filaments powers contractions, and the entire system is held in place by a structure called the Z-disc, which anchors the actin filaments. Myosin filaments, in turn, are anchored to another structure called the M-line. Most of the complex architecture of myofibrils can be reduced to studying the Z-disc, and recently, important advances regarding the arrangement and function of Z-discs in insects have been published. On a very small scale, we have detailed protein structure information. At the medium scale, we have cryo-electron microscopy maps, super-resolution microscopy and protein–protein interaction networks, while at the functional scale, phenotypic data are available from precise genetic manipulations. All these data aim to answer how the Z-disc works and how it is assembled. Here, we summarize recent data from insects and explore how it fits into our view of the Z-disc, myofibrils and, ultimately, muscles.
Funder
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Publisher
The Company of Biologists