Affiliation:
1. Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK
Abstract
Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. Tbe PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signalling. Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to PCP. Reorganization of the cell surface and cytoskeleton is required, and recent work has focused on how cell adhesion molecules (such as Fat, Dachsous and Flamingo) function in this process.
Publisher
The Company of Biologists
Reference59 articles.
1. Adler, P. N., Vinson, C., Park, W. J., Conover, S. and Klein, L. (1990). Molecular structure of frizzled, a Drosophila tissue polarity gene. Genetics126, 401-416.
2. Adler, P. N., Krasnow, R. E. and Liu, J. (1997). Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels. Curr. Biol.7, 940-949.
3. Adler, P. N., Charlton, J. and Liu, J. (1998). Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling. Development125, 959-968.
4. Adler, P. N., Taylor, J. and Charlton, J. (2000). The domineering non-autonomy of frizzled and van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling. Mech. Dev.96, 197-207.
5. Axelrod, J. D. (2001). Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev.15, 1182-1187.
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