Biogenesis of caveolae: a structural model for caveolin-induced domain formation
Author:
Parton Robert G.12, Hanzal-Bayer Michael1, Hancock John F.1
Affiliation:
1. Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia 2. Centre for Microscopy and Microanalysis, University of Queensland, Queensland 4072, Australia
Abstract
Caveolae are striking morphological features of the plasma membrane of mammalian cells. Caveolins, the major proteins of caveolae, play a crucial role in the formation of these invaginations of the plasma membrane; however, the precise mechanisms involved are only just starting to be unravelled. Recent studies suggest that caveolae are stable structures first generated in the Golgi complex. Their formation and exit from the Golgi complex is associated with caveolin oligomerisation, acquisition of detergent insolubility, and association with cholesterol. Modelling of caveolin-membrane interactions together with in vitro studies of caveolin peptides are providing new insights into how caveolin-lipid interactions could generate the unique architecture of the caveolar domain.
Publisher
The Company of Biologists
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