Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient-Reference-Cited by-同舟云学术

Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient

Published:2012-08-01 Issue:15 Volume:139 Page:2721-2729
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Stinchfield Michael J.¹,Takaesu Norma T.¹,Quijano Janine C.¹,Castillo Ashley M.¹,Tiusanen Nina²,Shimmi Osamu²,Enzo Elena³,Dupont Sirio³,Piccolo Stefano³,Newfeld Stuart J.¹

Affiliation:

1. School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA

2. Institute of Biotechnology, University of Helsinki, Helsinki, Finland

3. Department of Biomedical Sciences, University of Padova Medical School, Padova, Italy

Abstract

The ability of secreted Transforming Growth Factor β (TGFβ) proteins to act as morphogens dictates that their influence be strictly regulated. Here, we report that maternally contributed fat facets (faf; a homolog of USP9X/FAM) is essential for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that patterns the embryonic dorsal-ventral axis. The data suggest that the loss of faf reduces the activity of Medea (a homolog of Smad4) below the minimum necessary for adequate Dpp signaling and that this is likely due to excessive ubiquitylation on a specific lysine. This study supports the hypothesis that the control of cellular responsiveness to TGFβ signals at the level of Smad4 ubiquitylation is a conserved mechanism required for proper implementation of a morphogen gradient.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/139/15/2721/1477377/2721.pdf

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