Contextual modulation of multifunctional central pattern generator

Abstract

Abstract The multifunctional buccal central pattern generator in snails controlling different oral behaviors has been well characterized. In this work we propose a role for the group of 40 electrotonically coupled buccal A cluster cells as a context dependant switch for the buccal CPG, modulating motor patterns eliciting different oral behaviors. We characterize these cells based on location and morphology and provide evidence for their selective activation under two different stimuli - Listerine perfusion and intestinal nerve stimulation - triggering buccal motor patterns putatively underlying egestion and substrate cleaning. Using paired intracellular recordings of buccal cluster cells and monitor motor neurons of the buccal CPG we show a new role for these electrotonically coupled neurons as a context dependant switch that alters buccal motor patterns depending on input stimuli, thereby eliciting appropriate behavioral responses.