Affiliation:
1. Karolinska Institute, Department of Cell and Molecular Biology, Biomedicum, Solnavägen 9, 17163 Stockolm, Sweden
Abstract
ABSTRACT
Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells, tissues and organs sense and regenerate missing or damaged parts. In this Primer, we cover the evolutionary context in which salamanders emerged. We outline the varieties of mechanisms deployed during salamander regeneration, and discuss how these mechanisms are currently being explored and how they have advanced our understanding of animal regeneration. We also present arguments about why it is important to study closely related species in regeneration research.
Funder
Vetenskapsrådet
Hjärnfonden
Knut och Alice Wallenbergs Stiftelse
Stiftelsen Olle Engkvist Byggmästare
National Institutes of Health
Cancerfonden
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
107 articles.
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