Affiliation:
1. Molecular and Cell Biology, University of California, Berkeley, CA 94720,USA.
2. Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Abstract
In the nematode Caenorhabditis elegans, neurons are generated from asymmetric divisions in which a mother cell divides to produce daughters that differ in fate. Here, we demonstrate that the gene pig-1 regulates the asymmetric divisions of neuroblasts that divide to produce an apoptotic cell and either a neural precursor or a neuron. In pig-1 mutants,these neuroblasts divide to produce daughters that are more equal in size, and their apoptotic daughters are transformed into their sisters, leading to the production of extra neurons. PIG-1 is orthologous to MELK, a conserved member of the polarity-regulating PAR-1/Kin1/SAD-1 family of serine/threonine kinases. Although MELK has been implicated in regulating the cell cycle, our data suggest that PIG-1, like other PAR-1 family members, regulates cell polarity.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Reference65 articles.
1. Blot, J., Chartrain, I., Roghi, C., Philippe, M. and Tassan, J. P. (2002). Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family. Dev. Biol.241,327-338.
2. Branda, C. S. and Stern, M. J. (2000). Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Dev. Biol.226,137-151.
3. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics77, 71-94.
4. Bulow, H. E., Boulin, T. and Hobert, O. (2004). Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position. Neuron42,367-374.
5. Chartrain, I., Couturier, A. and Tassan, J. P.(2005). Cell cycle dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. Biol. Cell. 98,253-263.
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