Affiliation:
1. Hubrecht Laboratory, Netherlands Institute for Developmental Biology,Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Abstract
The Hox genes confer positional information to the axial and paraxial tissues as they emerge gradually from the posterior aspect of the vertebrate embryo. Hox genes are sequentially activated in time and space, in a way that reflects their organisation into clusters in the genome. Although this co-linearity of expression of the Hox genes has been conserved during evolution, it is a phenomenon that is still not understood at the molecular level. This review aims to bring together recent findings that have advanced our understanding of the regulation of the Hox genes during mouse embryonic development. In particular, we highlight the integration of these transducers of anteroposterior positional information into the genetic network that drives tissue generation and patterning during axial elongation.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Reference97 articles.
1. Abu-Abed, S., Dollé, P., Metzger, D., Beckett, B.,Chambon, P. and Petkovich, M. (2001). The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev.15,226-240.
2. Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler,A., Kanzler, B. and Herrmann, B. G. (2003). Wnt3aplays a major role in the segmentation clock controlling somitogenesis. Dev. Cell4,395-406.
3. Beck, F., Tata, F. and Chawengsaksophak, K.(2000). Homeobox genes and gut development. BioEssays22,431-441.
4. Beddington, R. S. (1994). Induction of a second neural axis by the mouse node. Development120,613-620.
5. Bel-Vialar, S., Itasaki, N. and Krumlauf, R.(2002). Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development129,5103-5115.
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