The brain on time: links between development and neurodegeneration

Author:

Shabani Khadijeh1,Hassan Bassem A.1ORCID

Affiliation:

1. Institut du Cerveau – Paris Brain Institute – ICM, Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière , 75013 Paris , France

Abstract

ABSTRACT Neurodegenerative diseases are characterized by the progressive loss of structure or function of neurons. In this Spotlight, we explore the idea that genetic forms of neurodegenerative disorders might be rooted in neural development. Focusing on Alzheimer's, Parkinson's and Huntington's disease, we first provide a brief overview of the pathology for these diseases. Although neurodegenerative diseases are generally thought of as late-onset diseases, we discuss recent evidence promoting the notion that they might be considered neurodevelopmental disorders. With this view in mind, we consider the suitability of animal models for studying these diseases, highlighting human-specific features of human brain development. We conclude by proposing that one such feature, human-specific regulation of neurogenic time, might be key to understanding the etiology and pathophysiology of human neurodegenerative disease.

Funder

Institut du Cerveau-Paris Brain Institute

Agence Nationale de la Recherche

National Institutes of Health

Association France Alzheimer

Fondation Roger de Spoelberch

Fonds de Dotation Neuroglia

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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