Spontaneous alternation behavior in larval zebrafish

Author:

Bögli Stefan Yu1,Huang Melody Ying-Yu123ORCID

Affiliation:

1. Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland

2. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Switzerland

3. Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Switzerland

Abstract

Spontaneous alternation behavior (SAB) describes the tendency of animals to alternate their turn direction in consecutive turns. SAB, dissimilar from other mnestic tasks, does not require any prior training or reinforcement. Due to its close correlation to the development and function of hippocampus in mice, it is thought to reflect a type of memory. Adult zebrafish possess a hippocampus-like structure utilizing the same neurotransmitters as in human brains, and have thus been used to study memory. In the current study we established SAB in zebrafish larvae at 6 days post fertilization using a custom made forced-turn maze with a rate of 57%. Our demonstration of SAB's presence in larval zebrafish at a very early developmental stage not only provides evidence for early cognition in this species but suggests its future use as a high-throughput model for mnestic studies.

Funder

Betty and David Koetser Foundation for Brain Research

Dr. Dabbous-Foundation

Publisher

The Company of Biologists

Subject

Insect Science,Molecular Biology,Animal Science and Zoology,Aquatic Science,Physiology,Ecology, Evolution, Behavior and Systematics

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