Affiliation:
1. Centre for Organismal Studies, Heidelberg University, Heidelberg 69120, Germany
2. Heidelberg Biosciences International Graduate School, Heidelberg 69120, Germany
Abstract
ABSTRACT
How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (Oryzias latipes), a well-studied system with which to address vertebrate organ growth. We reveal that a central growth regulator, Igf1 receptor (Igf1r), is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche: the ciliary marginal zone (CMZ). Targeted activation of Igf1r signaling in the CMZ uncouples neuroretina growth from body size control, and we demonstrate that Igf1r operates on progenitor cells, stimulating their proliferation. Activation of Igf1r signaling increases retinal size while preserving its structural integrity, revealing a modular organization in which progenitor differentiation and neurogenesis are self-organized and highly regulated. Our findings position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications.
Funder
Studienstiftung des Deutschen Volkes
European Research Council
Deutsche Forschungsgemeinschaft
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
10 articles.
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