Affiliation:
1. Department of Biology, Technion- Israel Institute of Technology, Haifa 3200003, Israel
Abstract
Mitochondria respond to environmental cues and stress conditions. Additionally, the disruption of the mitochondrial network dynamics and its distribution is implicated in a variety of neurodegenerative diseases. We reveal a novel function for Myo19 in mitochondrial dynamics and localization during the cellular response to glucose starvation. Ectopically expressed Myo19 localizes with mitochondria to the tips of starvation-induced filopodia. Corollary to this, RNAi mediated knockdown of Myo19 diminished their formation without evident effects on the mitochondrial network. We analyzed Myo19 mitochondria interaction and demonstrated that it is uniquely anchored to the outer mitochondrial membrane (OMM) via a 30-45-residue motif, indicating that Myo19 is a stably attached OMM molecular motor. Our work reveals a novel function for Myo19 in mitochondrial positioning under stress.
Publisher
The Company of Biologists
Cited by
51 articles.
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