Phylogenetic analysis of mammalian maximal oxygen consumption during exercise

Abstract

Summary We compiled published values of mammalian maximum oxygen consumption during exercise (VO2max) and supplemented these data with new measurements of VO2max for the largest rodent (capybara), 20 species of smaller-bodied rodents, two species of weasels, and one small marsupial. Many of the new data were obtained with running-wheel respirometers instead of the treadmill systems used in most previous measurements of mammalian VO2max. We used both conventional and phylogenetically informed allometric regression models to analyze VO2max of 77 ‘species’ (including subspecies or separate populations within species) in relation to body size, phylogeny, diet, and measurement method. Both body mass and allometrically mass-corrected VO2max showed highly significant phylogenetic signal (i.e., related species tended to resemble each other). The Akaike Information Criterion corrected for sample size was used to compare 27 candidate models predicting VO2max (all of which included body mass). In addition to mass, the two best-fitting models (cumulative Akaike weight = 0.93) included dummy variables coding for three species previously shown to have high VO2max (pronghorn, horse, and a bat), and incorporated a transformation of the phylogenetic branch lengths under an Ornstein-Uhlenbeck model of residual variation (thus indicating phylogenetic signal in the residuals). We found no statistical difference between wheel- and treadmill-elicited values, and diet had no predictive ability for VO2max. Averaged across all models, the allometric scaling exponent was 0.839, with 95% confidence limits of 0.795 and 0.883, which does not provide support for a scaling exponent of 0.67, 0.75 or unity.