Epithelial-mesenchymal transitions: insights from development-Reference-Cited by-同舟云学术

Epithelial-mesenchymal transitions: insights from development

Published:2012-10-01 Issue:19 Volume:139 Page:3471-3486
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Lim Jormay¹,Thiery Jean Paul¹²

Affiliation:

1. Institute of Molecular Cell Biology, A*STAR, 61 Biopolis Drive, 138673, Singapore.

2. Cancer Science Institute, National University of Singapore, 14 Medical Drive, 117599, Singapore.

Abstract

Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that occurs during development and is essential for shaping embryos. Also implicated in cancer, this morphological transition is executed through multiple mechanisms in different contexts, and studies suggest that the molecular programs governing EMT, albeit still enigmatic, are embedded within developmental programs that regulate specification and differentiation. As we review here, knowledge garnered from studies of EMT during gastrulation, neural crest delamination and heart formation have furthered our understanding of tumor progression and metastasis.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/139/19/3471/1159752/3471.pdf

Reference211 articles.

1. MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells;Abell;Cell Stem Cell,2011

2. Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation;Acloque;Dev. Cell,2011

3. The neural crest epithelial-mesenchymal transition in 4D: a ‘tail’ of multiple non-obligatory cellular mechanisms;Ahlstrom;Development,2009

4. New views on the neural crest epithelial-mesenchymal transition and neuroepithelial interkinetic nuclear migration;Ahlstrom;Commun. Integr. Biol.,2009

5. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse;Arnold;Development,2008

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