A new model for random X chromosome inactivation
Author:
Starmer Joshua12, Magnuson Terry1
Affiliation:
1. Department of Genetics and the Carolina Center for the Genome Sciences, and University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 2. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Abstract
X chromosome inactivation (XCI) reduces the number of actively transcribed X chromosomes to one per diploid set of autosomes, allowing for dosage equality between the sexes. In eutherians, the inactive X chromosome in XX females is randomly selected. The mechanisms for determining both how many X chromosomes are present and which to inactivate are unknown. To understand these mechanisms, researchers have created X chromosome mutations and transgenes. Here, we introduce a new model of X chromosome inactivation that aims to account for the findings in recent studies, to promote a re-interpretation of existing data and to direct future experiments.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Reference54 articles.
1. Augui, S., Filion, G. J., Huart, S., Nora, E., Guggiari, M.,Maresca, M., Stewart, A. F. and Heard, E. (2007). Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic. Science318,1632-1636. 2. Bacher, C. P., Guggiari, M., Brors, B., Augui, S., Clerc, P.,Avner, P., Eils, R. and Heard, E. (2006). Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat. Cell Biol.8, 293-299. 3. Borsani, G., Tonlorenzi, R., Simmler, M. C., Dandolo, L.,Arnaud, D., Capra, V., Grompe, M., Pizzuti, A., Muzny, D., Lawrence, C. et al. (1991). Characterization of a murine gene expressed from the inactive X chromosome. Nature351,325-329. 4. Brockdorff, N., Ashworth, A., Kay, G. F., Cooper, P., Smith, S.,McCabe, V. M., Norris, D. P., Penny, G. D., Patel, D. and Rastan, S.(1991). Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature351,329-331. 5. Brown, C. J., Ballabio, A., Rupert, J. L., Lafreniere, R. G.,Grompe, M., Tonlorenzi, R. and Willard, H. F. (1991a). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature349, 38-44.
Cited by
72 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|