Affiliation:
1. University of Bialystok;
2. Nencki Institute of Experimental Biology, Warsaw
Abstract
Summary
Dietary restriction (DR)-related delay of ageing is hypothesized to be mediated by the reduction of the metabolic rate (MR). However, studies on the effect of DR on MR have produced equivocal results. We demonstrated that this lack of congruency can be due to a variation in the initial level of MR within a given pool of experimental subjects. We subjected laboratory mice from two line-types divergently selected for basal MR (BMR) to 30% DR lasting 6 months, to test whether the effect of DR depends on the initial variation in BMR and peak MR. BMR and peak MR were independently affected by DR. The effect of DR was stronger in line-types with higher initial levels of MR. Line-type specific changes in the proportions of body components explained contrasting effects of DR on the mass-corrected BMR, which decreased in the high, and did not change in the low BMR line-type. We conclude that the initial variation in MR can significantly affect response to DR. However, we found no association between the level of MR and mechanisms underlying susceptibility to or protection against oxidative stress.
Publisher
The Company of Biologists
Subject
Insect Science,Molecular Biology,Animal Science and Zoology,Aquatic Science,Physiology,Ecology, Evolution, Behavior and Systematics
Reference47 articles.
1. Metabolic reprogramming, caloric restriction and aging;Anderson;Trends Endocrinol. Metab.,2010
2. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: implications for aging studies;Barja;Rejuvenation Res.,2007
3. Anatomic and molecular correlates of divergent selection for basal metabolic rate in laboratory mice;Brzęk;Physiol. Biochem. Zool.,2007
4. Age and aerobic performance in deer mice;Chappell;J. Exp. Biol.,2003
5. Calorie restriction in mice: effects on body composition, daily activity, metabolic rate, mitochondrial reactive oxygen species production, and membrane fatty acid composition;Faulks;J. Gerontol. A Biol. Sci. Med. Sci.,2006
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