The Personalized Algorithm of the “Tension-Type Headache and Arterial Hypertension” Phenotype Diagnosis

Abstract

The tension-type headache (TTH) and arterial hypertension (AH) are one of the most common conditions worldwide. The cumulative assessment of clinical and genetic predictors needs to be revised. The aim is designing a scale and algorithm for predicting the risk of the “TTH + AH” phenotype developing in outpatient clinics. The leading non-genetic predictors are emotional lability and personal uneasiness. The leading genetic predictor is the carriage of the minor T allele and the heterozygous CT genotype rs3782218, as well as heterozygous genotype GA rs7314935 of the NOS1 gene encoding neuronal nitric oxide synthase. There are scale and personalized algorithm for assessing the risk of the “TTH + AH” phenotype development. There is the higher the score, the higher the risk of “TTH + AH” phenotype development in hypertensive patients. The using of the presented scale and algorithm will allow timely identification of a risk group for the “TTH + AH” phenotype and avoid diagnostic errors.