Keeping pace with the times, this paper analyzes and interprets the concept, characteristics of Metaverse, and its influence on new media communication. Based on this, under the topological characteristics of information communication, this paper discusses the transformation of new media communication paradigm in the metaverse era and models the prediction of new media information dissemination in metaverse. In this paper, the multi-agent modeling method is used to analyze and compare the evolution results of each agent attribute under different parameter values. At the same time, based on the ideal social media network, the improved integrated immune control strategy is applied to the dynamic model of epidemic (SEIR) with latent period, and the spreading and evolution process of rumors before and after immunization is simulated. This research has both theoretical value and practical application value, which can provide a useful reference for the follow-up research of new media communication.