An Overview of the Genetics of Parkinson's Disease-Reference-Cited by-同舟云学术

An Overview of the Genetics of Parkinson's Disease

Published:2023-08-04 Issue: Volume: Page:164-181
ISSN:2475-6628
Container-title:Experimental and Clinical Evidence of the Neuropathology of Parkinson’s Disease
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Author:

Aimrane Abdelmohcine¹,Sabir Es-Said²^ORCID,Laadraoui Jawad²^ORCID,El-Mansoury Bilal²,Smimih Kamal³,Khanouchi Manal²,El Amine Souad²,Lafhal Karima²,Oublal Karima²,El Baz Soraia⁴,Mountassir Meriem²,Saad Fatima Ez-Zahraa²,Draoui Ahmed⁵^ORCID,Abdelmonaim El Hidan Moulay²,Ferssiwi Abdessalam²,Bitar Abdelali²,Fdil Naima²

Affiliation:

1. Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco

2. Independent Researcher, Morocco

3. Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Mococco

4. Laboratory BioMagE, Labeled Unit-CNRST N°4, FSSM,UCA, Morocco

5. Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco

Abstract

While the etiology of Parkinson's disease (PD) in most cases remains unknown, 10-15% of PD patients show a prognosis of monogenic forms of the disease with classical Mendelian type of inheritance. Indeed, the identified causative mutations contribute to dopaminergic neurons degeneration. In spite of the rarity of the genetic forms of PD, new molecular pathways are likely to be identified which are relevant in the sporadic form as well. In this chapter, the authors represent an update on the most relevant advances in the genetics of PD.

Publisher

IGI Global

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