Natural Products as Alternative Treatments for Bone Disorders

Abstract

Bone is an active and dynamic organ that is well-differentiated and originated from mesenchymal cells. Bone goes through constant remodeling during its lifetime. Most bone disorders result in loss of bone mass and microarchitectural deterioration, which leads to more osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Natural products have been used to treat bone disorders since ancient times and have gained favor in recent years. Natural products have grown in popularity worldwide over the last few decades, according to the World Health Organization (WHO), and are now used by 80% of the world's population. This chapter explores the pharmacological actions of some medicinal plants, including Marantodes pumilum, Eurycoma longifolia, and Piper sarmentosum for bone repair. This chapter includes the extensive study of medicinal plants and active compounds with their potential usage in treating bone disorders, as well as the molecular mechanisms underlying their action in reducing osteoclast formation and activity.