Affiliation:
1. The Assam Royal Global University, India
Abstract
Glioblastoma is the most aggressive primary malignant brain tumor in adults. Complex genetic and molecular changes that cause unchecked cell proliferation, invasion of the surrounding brain tissue, and angiogenesis are the hallmarks of the physiopathology of glioblastoma. Although there are treatment options for this deadly tumor that include surgery, radiation, and chemotherapy, the blood-brain barrier and the tumor's infiltrative nature restrict their effectiveness, frequently leading to tumor recurrence and illness progression. To create new therapeutic approaches and enhance patient outcomes, it is crucial to comprehend the physiopathology of glioblastoma and its associated consequences. To improve treatment and quality of life for patients with glioblastoma, further research is required to clarify molecular causes, discover therapeutic targets, and address the difficulties provided by comorbidities.