Astrocytes Reprogramming for Neurodegenerative Disease Management

Author:

Tamegart Lahcen1,Hilali Rabii1,Ouaki Hajar2,Rachidi Fatima3,Chakir Ibtissam4,Ajana Rabia5,Oudghiri Dia Eddine5ORCID,Draoui Ahmed6ORCID,Oukhrib Mjid7ORCID,El Ghachi Hafida6ORCID,Ben Maloui Abdelali6,El Khiat Abdelaati8,Gamrani Halima6

Affiliation:

1. Abdelmalek Essaâdi University, Morocco

2. Biology Department, Higher School of Teachers (ENS), Mohammed V University in Rabat, Morocco

3. Mohammed V University in Rabat, Morocco

4. Sultan Moulay Slimane University, Morocco

5. Abdelmalek Essaadi University, Morocco

6. Cadi Ayyad University, Morocco

7. Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco

8. Independent Researcher, Morocco

Abstract

Neurodegenerative disorders (NDD) are chronic conditions that lead to nerve cells degeneration in the central nervous system. The most common NDD are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington's disease (HD). Parkinson's disease (PD) is recognized as the second most common neurodegenerative disease after Alzheimer's disease (AD) and Huntington disease (HD). Astrocytes reprogramming has been recently proposed as one of the most important treatments to stop the progression of these neurological diseases. By targeting the microRNA, astrocytes in the animal brain could be reprogrammed into various functional neural systems. Activation of endogenous genes could be a revolutionary therapeutic approach for treating neurological diseases. Reprogrammed astrocytes could also be used to generate various types of neurons lost in case of Huntington's disease, Parkinson's disease, and Alzheimer's disease. The ability to reprogram astrocytes into functional neurons was classified as a new advancement for PD, AD, and HD treatments.

Publisher

IGI Global

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3