Based on real situations that mankind is confronting with the difficult era; insufficiency in food supplies, natural disasters, epidemic, etc. The paper is to econometrically compute portfolio optimization and predict efficiency frontiers for solving the most sensible scenario to suggest a sustainable policy in the three important pillars such as the growth of economic systems, environmental management, and public healthcare. The main observations are annual time-series information between 2000 and 2017 and collected from three countries in ASEAN. Singapore, Thailand, and Malaysia are the target. Methodologically, this research is to apply the quantum mechanism and the wave function for clarifying a real data distribution; true mean, and standard deviation of the data. These outcomes are the initial raw material for the modern portfolio optimization (for short-run policies) and efficient frontier computation (for long-term policies). Empirically, the results show some exclusive issues that can be the help for managing feasible budget allocations fairly and sustainably.