Comparative Evaluation of Dinoprostone Gel and Pessary for Labor Induction on Efficacy and Safety Assessment

Abstract

Labor induction is used to start labour when medical or obstetric symptoms occur. Dinoprostone, a prostaglandin E2 analogue, is widely synthesised for this purpose. Dinoprostone is mostly used as gel and pessary, which have different application ways but the same active ingredient. This study examined the safety and efficacy of pessary and dinoprostone gel for labour induction, focusing on fetomaternal outcomes. A prospective randomised controlled trial included 300 healthy pregnant moms who met labor-inducing criteria. Participants were randomly assigned Pessary or Dinoprostone gels. Inducing labour was the major goal, while uterine hyperstimulation, maternal side effects, newborn Apgar scores, neonatal resuscitation, and NICU admissions were secondary endpoints. The statistical tests were used to analyse the data. Labor induction success rates for Dinoprostone gel and pessaries were 85 and 87 percent, respectively. Neither group had more maternal side effects or uterine hyperstimulation. The groups had similar infant Apgar ratings at 1 and 5 minutes, NICU admissions, and resuscitation needs. This study concludes that pessary and dinoprostone gel induce labour safely and effectively. Selecting between the two categories based on clinical indications and patient characteristics supports personalised obstetrics treatment. The findings demonstrate dinoprostone's safety and efficacy in labour induction and support clinical decision-making.