Cerebroplacental Ratio and Cerebrouterine Ratio as Predictors of Adverse Neonatal Outcomes in Preeclamptic Pregnant Women

Abstract

Preeclampsia is a hypertensive pregnancy illness linked to poor outcomes for the unborn child. While the “cerebrouterine ratio (CU)” is a new measure that represents both the uterine circulation of the mother and the cerebral circulation of the foetus, the “cerebroplacental ratio (CP)” is a well-established Doppler parameter for foetal assessment. The purpose of this research was to assess how well preeclamptic pregnancies' diagnostic features for CP and CU predicted unfavourable newborn outcomes. A prospective cohort research comprising 300 pregnant women at risk of preeclampsia. Doppler ultrasonography was used to calculate CP and CU. Preterm birth, IUGR, and perinatal mortality were examples of adverse neonatal outcomes. Diagnostic features were evaluated, and receiver operating characteristic (ROC) curves were produced. When the threshold was set at 0.85, CP showed excellent sensitivity and specificity, with an AUC of 0.82. CU demonstrated great specificity (91.3%) at the 0.80 threshold. Combining CP and CU improved risk categorization by offering a thorough evaluation of foetal well-being. CP and CU are useful instruments for evaluating risk in preeclampsia. With its high specificity, CU detects high-risk cases, whereas CP's sensitivity makes it a useful screening tool. Their complementary qualities improve risk assessment, supporting clinical judgment. More research is necessary to validate these results and determine the best cutoff values for various clinical settings. In preeclampsia, CP, and CU show promise as indicators of unfavourable neonatal outcomes. When used singly or in combination, they can enhance clinical management and risk assessment, which may improve outcomes for mothers and newborns in preeclamptic pregnancies.