Although the evidence overwhelmingly supports hand hygiene as the most effective intervention to prevent infections, suboptimal hand hygiene practices continue. However, the COVID-19 pandemic has brought infection control to the forefront in every healthcare setting. As a result, this manuscript proposes adoption of universal hand hygiene, the practice in which all who enter the healthcare setting regardless of role perform hand hygiene as indicated. Adopting universal hand hygiene promotes high quality care, a clean and safe environment, and individual involvement. Issues regarding hand hygiene adherence may include lack of management support, ambiguity, ability, or agreement. As a result, this manuscript will address the role of management, knowledge, skills, and agreement related to universal hand hygiene in this multimodal, evidence-based practice (EBP) by modifying the previously published “Position on Healthcare Client Hand Hygiene.”