Computational Sequence Design Techniques for DNA Microarray Technologies-Reference-Cited by-同舟云学术

Computational Sequence Design Techniques for DNA Microarray Technologies

Published: Issue: Volume: Page:57-91
ISSN:2327-7033
Container-title:Systemic Approaches in Bioinformatics and Computational Systems Biology
language:
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Author:

Tulpan Dan¹,Ghiggi Athos²,Montemanni Roberto³

Affiliation:

1. National Research Council of Canada, Canada

2. University of Lugano (USI), Switzerland

3. Istituto Dalle Molle di Studi sull’Intelligenza Artificiale (IDSIA), Switzerland

Abstract

In systems biology and biomedical research, microarray technology is a method of choice that enables the complete quantitative and qualitative ascertainment of gene expression patterns for whole genomes. The selection of high quality oligonucleotide sequences that behave consistently across multiple experiments is a key step in the design, fabrication and experimental performance of DNA microarrays. The aim of this chapter is to outline recent algorithmic developments in microarray probe design, evaluate existing probe sequences used in commercial arrays, and suggest methodologies that have the potential to improve on existing design techniques.

Publisher

IGI Global

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