Since an e-portfolio system was adapted at the authors' college, the faculty has been encouraged to use e-portfolios in various areas from professional development to instructional purposes. In this paper, they describe two cases of faculty to discuss how they became collaborative partners who support each other in conceptualizing e-portfolios as an instructional tool, designing learning activities for graduate courses, and they reflect on their own practices for enhancing teaching and learning based on the results from interviews, reflective essays, questionnaires and participation in broader learning communities, and a review of their signature e-portfolio assignments. Additionally, they argue how broader teamwork at the college level helped them as faculty to continue their efforts, often supported by the administration. In conclusion, the importance of faculty partnership as well as a continuous support system for faculty in adapting a new technology will be discussed.