Leadership is crucial to the development and diffusion of e-government. But there is limited research that empirically validates this claim. This study thus examines the moderating effect of leadership commitment on the impact of infrastructure availability, financial capacity, literacy, and government policy and regulation toward the adoption of e-government. Data was obtained through a convenient sampling of Ghanaian citizens. The theory of the technology acceptance model (TAM) was applied, and the structural equation model technique was used to undertake the data analysis. The results showed that while leadership commitment significantly moderated the impact of infrastructure availability, finance capacity, and government policy and regulations on the perceived usefulness of e-government, its moderating effect on education/literacy on the perceived usefulness of e-government was not significant. Infrastructure, finance capacity, literacy, and government policy and regulations were significant predictors of e-government usefulness. Managerial and practical implications are discussed.