Alpha-Synucleinopathies

Author:

Camargo Carlos Henrique Ferreira1,Della-Coletta Marcus Vinicius2,José da Silva Delson3,Teive Hélio A. G.4

Affiliation:

1. Hospital Universitário dos Campos Gerais – UEPG, Brazil

2. State University of Amazonas, Brazil

3. Federal University of Goias, Brazil

4. Federal University of Paraná, Brazil

Abstract

Alpha-synuclein is a protein that forms a major component of abnormal neuronal aggregates known as Lewy bodies. A particular group of neurodegenerative disorders (NDs) is characterized by the abnormal accumulation of α-synuclein; termed the α-synucleinopathies, this group includes Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Lysosomal storage diseases have also been linked to α-synuclein toxicity. Several therapeutic targets have been chosen among steps of metabolism of α-synuclein. Reducing α-synuclein synthesis or expression and increasing the clearance can be achieved in many ways. The development of immunotherapeutic approaches targeting α-synuclein has received considerable attention in recent years. The aim of this chapter is to present the α-synucleinopathies, as well as to present the most recent researches about treatment of synucleinopathies based on knowledge of the pathophysiology of α-synuclein pathways.

Publisher

IGI Global

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