The Study of N-Nitrosoamines Formation in Model and Real Gastric Juice Systems

Author:

Gonta Maria Vasile1

Affiliation:

1. State University of Moldova, Moldova

Abstract

The formation of N-nitrosamines in gastric juice during the nitrosation of secondary amines by nitrite ions has been investigated. It has been established that the ratio of nitrosation of amines in gastric juice is higher than in model systems due to the presence of catalysts. On the nitrosation of the formed metabolites generated during the proteolysis of casein and albumin in gastric juice, the rate of this process is pH and enzyme activity dependent. The dihydroxyfumaric acid and sodium dihydroxy fumarate demonstrate inhibition properties during the formation of N-nitrosamines in gastric juice at the proteolysis of proteins in the presence of different proteolysis enzymes. The result of the comparative study demonstrates that the rate of NO2-consumption in the presence of DFH4 is the highest, while the constants of the reaction speed vary as follows kDFH4(0,94•102 M-1s-1) > kAAs (0,6•102 M-1s-1) > k (+) Ct (0,4•102 M-1s-1).

Publisher

IGI Global

Reference40 articles.

1. Anne, Roisin, & Jane. (2002). Effect of White Versus Red Meat on Endogenous N-Nitrosation in the uman Colon and Further Evidence of a Dose Respons. American Society for Nutritional Sciences.

2. Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?

3. Salivary Nitrate, Nitrite and Nitrate Reductase Activity in Relation to Risk of Oral Cancer in Egypt

4. Challis. Chemistry and biology of nitrosated peptides;C.Brain;Cancer Surveys,1989

5. Genotoxic and carcinogenic risk to humans of drug–nitrite interaction products

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