Recent Advancement to Improve Intestinal Absorption of Macromolecular Drugs

Abstract

Therapy of many ailments such as malignancy hepatitis, AIDS, cardiovascular diseases are carried out by using biological macromolecular drugs such as fusion protein drugs and antibodies. The majority of macromolecular drugs are either proteins or peptides, which are made into solution or suspension and are administered through intravenous or subcutaneous route that are invasive and painful. A significant level of attention has been given to oral macromolecular drug delivery over the last 30 years. The major obstruction faced by macromolecular drugs administered through oral route is the physical and biochemical properties of the epithelial layer of the gastrointestinal tract, which acts as a boundary. The chapter focuses on the physiological hindrance faced by protein and peptide during their conveyance through the GIT. Moreover, discussion about techniques that are used for dodging the boundaries and for enhancing the penetration of drug through GIT have been done. These methodologies can be of great value for absorption of drugs like bio macromolecules through the intestines.