Emergence of Advanced Manufacturing Techniques for Engineered Polymeric Systems in Cancer Treatment

Abstract

Clinical performances of chemotherapeutic drugs which are used to manage different stages of cancers are usually facing numerous pharmacological challenges such as tumor microenvironment, high dose requirements, poor selectivity towards cancer cells, life-threatening cytotoxicity, and frequent drug resistance incidences, in addition to pharmacotechnical issues such as poor aqueous solubility, uncontrolled drug-release, low stability, non-specific bio-distribution, and erratic bioavailability profiles. The chapter aims to provide a brief account of advancements made in nanotechnology-enabled manufacturing engineering tools for manipulating polymeric materials as efficient carriers so that loaded anti-cancer drugs would exhibit better therapeutic applications and optimized clinical significance in cancers.