ER Stress Signaling in Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is the most common etiology of dementia amongst aged individuals and a principal public health-related abnormality. It is considered as a multifactorial disorder, with no particular origin identified, and also some modifiable, as well as non-modifiable threats are correlated with its progression and development. The endoplasmic reticulum (ER) stress response is considered as a key process in the pathogenesis of AD. In this chapter, the authors present a summary of related transmembrane kinase proteins responsible for the onset of AD as well as show the interrelationship between ER stress and AD. Finally, the authors demonstrate the therapeutics intervention for AD diagnosis by highlighting the current practices to advance novel therapies.