Proteostasis and Neurodegeneration

Abstract

Proteostasis or protein homeostasis consists of a complex interrelated cellular system that controls several steps of protein quality and function from the initial step of synthesis as well as folding, and eventually degradation over enormous biochemical pathways. Proteostasis involves controlling protein folding, modification of the post-translational protein, and degradation of misfolded protein. However, the failure of proteostasis has resulted to produce a toxic protein that leads to disrupt aging and neurodegeneration. Additionally, endoplasmic reticulum degradation and autophagy dysfunction may outcome in cellular additional stress that is responsible for cell death. Consequently, proteostasis targets provide an element of a promising neuronal protective therapeutic method to improve the development of these diseases as well. In this chapter, the authors represent the current knowledge regarding how cellular proteostasis interruption contributes to progress neurodegenerative disorders.