Proteostasis and Neurodegeneration

Author:

Rahman Md. Ataur1ORCID,Rahman Md Saidur2ORCID,Uddin Md Jamal3ORCID,Mamun-Or-Rashid A. N. M.4,Rahman Md. Rezanur5ORCID,Pang Myung-Geol2,Rhim Hyewhon1

Affiliation:

1. Korea Institute of Science and Technology, South Korea

2. Chung-Ang University, South Korea

3. Ewha Womans University, South Korea

4. Doshisha University, Japan

5. Khwaja Yunus Ali University, Bangladesh

Abstract

Proteostasis or protein homeostasis consists of a complex interrelated cellular system that controls several steps of protein quality and function from the initial step of synthesis as well as folding, and eventually degradation over enormous biochemical pathways. Proteostasis involves controlling protein folding, modification of the post-translational protein, and degradation of misfolded protein. However, the failure of proteostasis has resulted to produce a toxic protein that leads to disrupt aging and neurodegeneration. Additionally, endoplasmic reticulum degradation and autophagy dysfunction may outcome in cellular additional stress that is responsible for cell death. Consequently, proteostasis targets provide an element of a promising neuronal protective therapeutic method to improve the development of these diseases as well. In this chapter, the authors represent the current knowledge regarding how cellular proteostasis interruption contributes to progress neurodegenerative disorders.

Publisher

IGI Global

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3