Immune-Targeted Nanomedicine

Abstract

Immunotherapy has become a preferable candidate for many diseases in recent days. The infusion or administration of immune complexes or components to elicit the own immune response against a particular disease by attracting the antigen presenting cells against the disease causing organism and eliciting the T-cell mediated killing and further activating cell mediated immunity based on the processed surface antigens underlies the basic concept behind the immunotherapy. Immunotherapy can be applied for all course of diseases even in the treatment of cancer. The limitation in using immunotherapy is that it needs a proper delivery vehicle to reach the diseased spot to shows its pharmacokinetic property. In case of cancer, the immune components administered itself are not able to pertain and penetrate the solid tumor mass. Nanoparticles are small-sized particles which are generally specific in action used in the field of medicine. Nanoparticles aid in targeted drug delivery to the specific spots and immune targeting of nanoparticles is due to its enhanced permeability and retention (EPR).