Abstract
While infectious disease has left strong impressions on human society, this chapter is concerned with the impression human society has left on disease. Humans have done a great deal of work to manage and defeat infectious disease. This story is filled with all the travails that come with science in practice. It includes moments of triumph, like the discovery of vaccination, and ethical atrocities, like the Tuskegee Syphilis Study, which deserves to be explained in its own right. Other major topics include sanitation, grappling with information about transmission and epidemiology, the discovery of microorganisms, and the role of accidents in medical research.