Natural Products and Their Bioactive Compounds as Chemotherapeutics

Abstract

Cancer is the second world's deadliest disease. Despite substantial advancements in medical technology for cancer therapies, cancer mortality remains greater than projected, and cancer treatment requires additional study. The research carried out in natural products is due to the presence of bioactive compounds, unique structures, and mechanistic actions. Prevention of drug resistance in chemotherapy is predominant in the usage of anticancer drugs. Clinical chemotherapeutic medicines work by causing cancer cells to die, the majority of which is apoptotic. Another way to combat drug resistance in cancer therapy is circumventing apoptosis by targeting non-apoptotic cell death. The authors discussed in this chapter both apoptotic and non-apoptotic cell death.