In innovation and entrepreneurship education, how to effectively use big data technology to improve the quality of education has become an urgent problem. In this article, the authors summarize the development of big data technology and its application background in higher education and point out the limitations of traditional education quality evaluation methods. They discuss the research status of the quality evaluation of innovation and entrepreneurship education in colleges and universities at home and abroad and the application of big data in education quality evaluation. Using the fuzzy comprehensive evaluation method, they constructed a quality evaluation model of innovation and entrepreneurship education in colleges and universities based on big data and proposed a corresponding evaluation process and index system. Finally, through empirical analysis, they verified the effectiveness and operability of the evaluation model. This research has theoretical and practical significance for improving the quality of innovation and entrepreneurship education in colleges and universities.