Oxidative Stress and Neurodegeneration-Reference-Cited by-同舟云学术

Oxidative Stress and Neurodegeneration

Published:2019 Issue: Volume: Page:24-47
ISSN:2475-6628
Container-title:Advances in Medical Diagnosis, Treatment, and Care
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Author:

Osafo Newman¹^ORCID,Obiri David Darko¹,Danquah Kwabena Owusu¹,Yeboah Oduro Kofi¹^ORCID,Antwi Aaron Opoku¹,Oppong Mahmood Brobbey²

Affiliation:

1. Kwame Nkrumah University of Science and Technology, Ghana

2. University of Ghana, Ghana

Abstract

Neurons are the building units of the nervous system and are therefore critical units for the health of the brain and the spinal cord. This is necessitated by their inability to be either replaced or reproduced once lost. Their losses are implicated in a number of conditions which have been elaborated in this chapter. Oxidative stress has been strongly implicated in neurodegeneration through blockade of neuroprotection by a number of mechanisms including inhibitory effect on insulin-like growth factor I (IGF-1) via stimulation of the transcription factor, Forkhead box O3 (FOXO3). This chapter elaborates on these two phenomena which cannot be decoupled.

Publisher

IGI Global

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