Affiliation:
1. Tezpur University, India
Abstract
This chapter includes detailed review of the research undertaken with conducting polymer (CP) based composites with chitosan (Ch) for tissue engineering till date. The beneficial role of electrically conductive biomaterials has been discussed with the possible strategies to overcome the shortcomings of CP alone through blending with Ch due to its excellent biocompatibility, biodegradability, and bioactivity. Additionally, this embodiment deals with the optimization and characterization of electrically conductive, biocompatible and biodegradable Polyaniline: Chitosan (PAni:Ch) nanocomposites as cell culture substrates for MDA-MB-231 and NIH 3T3 fibroblast in order to examine the combined effect of nanofiber structure and surface modification on cell-biomaterial interactions. The nanocomposites were further checked as a conductive scaffold for electrical stimulation of a neuronal model PC12 cell line in order to explore the potential of the materials in neural tissue engineering.
Reference152 articles.
1. Ahuja, A. (2017, November 26). Lack of organ donation in India: Here is why half a million people die annually in India due to unavailability of organs. NDTV. Retrieved from http://sites.ndtv.com/moretogive/lack-organ-donation-india-half-million-people-die-annually-india-due-unavailability-organs-2107/
2. Brief Electrical Stimulation Promotes the Speed and Accuracy of Motor Axonal Regeneration
3. Polyaniline conducting electroactive polymers thermal and environmental stability studies.;R.Ansari;Journal of Chemistry,2006
4. Polypyrrole-based conducting polymers and interactions with biological tissues
5. Magnetic polyaniline-chitosan nanocomposite decorated with palladium nanoparticles for enhanced catalytic reduction of 4-nitrophenol