Affiliation:
1. Selvam College of Technology, India
2. Anna University, India
Abstract
Piperine is known for its versatile therapeutic activity. It has been used for various disease conditions (e.g., cold, cough, etc.). Piperine is an alkaloid found in black pepper. It possesses various pharmacological actions like anti-inflammatory, anti-oxidant, anti-cholinergic, and anti-cancerous. The above-mentioned properties will be studied by selecting target proteins COX-2 protein, angiotensin converting enzyme, acetylcholineesterases, and survivin using computational docking study. This chapter explains the inhibition property of piperine against selected target protein from the results of docking studies. Based on the docking scores and protein-ligand interactions, piperine was found to bind well in the active site of the selected target proteins. It ensures the binding efficacy of piperine against selected target proteins. Docking scores and protein-ligand interactions plays an important role in its therapeutic activity.
Reference33 articles.
1. Ahmad, Fazal, & Abbasi. (2012). Biological role of piper nigrum L. (Black pepper): A review. Asian Pacific Journal Tropical Biomedicine, 1945-1953.
2. Araz, Jac., & Bayly. (2002). Fast, Efficient Generation of High-Quality Atomic Charges. AM1-BCC Model: II. Parameterization and Validation. Journal of Computational Chemistry, 23(16), 1623–41.
3. Kinetics and Docking Studies of a COX-2 Inhibitor Isolated from Terminalia bellerica Fruits
4. Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid.
5. Chen, Duan, Zhang, & Zhang. (2016). Survivin and tumorigenesis: molecular mechanism and therapeutic strategies. Journal of Cancer, 7(3), 314-323.