Development of a Clinical Microvascular Imaging and Vascular Optics Facility

Abstract

The Newcastle Microvascular Diagnostics Service (MDS) provides a comprehensive array of optical and thermal technologies for assessing micro-circulatory blood flow and function. Thermography is a key modality, although the facility has capability for capillaroscopy, laser Doppler perfusion / speckle contrast imaging, as well as numerous non-imaging techniques. The test portfolio covers four main areas: connective tissue disease and Raynaud's phenomenon, specialist limb studies (i.e. amputation level, muscle compartment perfusion and venous physiology), neurovascular assessment, and burn wound depth assessment. The MDS greatly benefits from a state-of-the-art temperature and humidity-controlled clinical room, enabling thermal physiology investigations to be performed efficiently and with confidence. Extensive research and development (R&D) is also undertaken, with collaborations across a range of academic, clinical and industrial partners. This chapter summarizes the history and development of the MDS, tests performed, R&D undertaken, clinical management, and future service directions.