This journal article proposes a cross-business domain applied holistic mathematical model (AHMM) that is the result of a lifetime long research on business transformations, applied mathematics, software modelling, business engineering, financial analysis, and global enterprise architecture. This ultimate research is based on an authentic and proprietary mixed research method that is supported by an underlining mainly qualitative holistic reasoning model module. The proposed AHMM formalism attempts to mimic some functions of the human brain, which uses empirical processes that are mainly based on the beam-search, like heuristic decision-making process. The AHMM can be used to implement a decision-making system or an expert system that can integrate in the enterprise's business, information and communication technology environments. The AHMM uses a behaviour driven development environment or a natural language environment that can be easily adopted by the project's development teams. The AHMM offers a high level implementation environment that can be used by any team member without any prior computer sciences qualification. The AHMM can be used also to model enterprise architecture (EA) blueprints, business transformation projects, or knowledge management systems; it is supported by many real-life cases of various business domains. The uniqueness of this research is that the AHMM promotes a holistic unbundling process, the alignment of various EA standards and transformation strategies to support business transformation projects.