Throughout history, leaders in many countries have leveraged on technology to achieve supremacy and power; from German engineering and Japanese electronics to Indian software and Israeli cybersecurity. Patterns in the rise and fall of technological leadership show that such dominance should be understood from traditional factors that signal industrial power, geography and national ambition, and the complexity of emerging technologies. The ubiquitous nature of contemporary technologies and the explosion of mobile and other network-attached devices have been the catalysts and tipping points for most successful countries and leaders. This paper examines how advances in technology impact on university leadership effectiveness among academic staff working in four selected private universities in Ghana. Stratified random sampling method was used to gather data from respondents, comprising administrators, deans and heads of departments from four universities used in the study. Data was analysed using the Pearson's Product Moment Correlation and the one sample t-test. The study revealed that, advances in technology has a positive relationship with leadership. The authors proceed to discuss the implications of the study by way of theory, practice and future study.