This study aimed to predict the medical students' attitudes toward e-learning concerning their sensation-seeking traits during the COVID-19 pandemic lockdown. For this purpose, through a cross-sectional study, the required data was collected using two questionnaires from 921 students at a University of Medical Sciences. The findings showed that there is a significant negative correlation between the participants' attitudes toward e-learning regarding the four investigated personality traits, thrill and adventure seeking (TSA), experience seeking (ES), disinhibition (DIS), and boredom susceptibility (BS), r= -0.38, -0.20, -0.07, and -0.09, respectively (p < 0.05). In addition, the three traits of ES, TAS, and Dis could significantly predict 15.9% of the participants' attitudes toward e-learning. The findings imply that higher sensation seekers may not welcome e-learning programs.