All over the world, the real estate sector under construction industry is one of the most hazardous sectors. The jobs consist of high risks like accidents, fatalities, and injuries. Working with height, excavation, dust, noise, heavy machinery, and modern gadgets all are playing an extensive role in the work environment of the real estate sector. Over the past few years in developing and underdeveloped countries, construction work has increased. With the development of these sectors, occupational hazards, accidents, etc. are also getting increased. To focus on Real Estate 4.0, the study emphasizes health and safety performance with the integration of artificial intelligence. As Real Estate 4.0 becomes more real, it will lead to a new series of paradigm shifts. In this study, the authors have highlighted the new industrial health and safety issues and management based on an adaptation of various aspects of artificial intelligence.