Clustering Methods for Gene-Expression Data

Abstract

Clustering methods are used to place items in natural patterns or convenient groups. They can be used to place genes into clusters to have similar expression patterns across the tissue samples of interest. They can also be used to cluster tissues into groups on the basis of their gene profiles. Examples of the methods used are hierarchical agglomerative clustering, k-means clustering, self organizing maps, and model-based methods. The focus of this chapter is on using mixtures of multivariate normal distributions to provide model-based clusterings of tissue samples and of genes.