Risk Assessment of Cosmetic Preservatives Using QSAR

Abstract

Cosmetic manufacturers need to demonstrate the safety and efficacy of the products against microbial contamination to assure consumer safety and to improve shelf-life. The preservation strategies include chemical, physical, or physiological strategies. The most common is the use of antimicrobial agents. The toxicity assessment of preservatives used in cosmetic products is essential. It can be done by computational methods such as quantitative structure-activity relationship (QSAR) using several software such as ADME-Tox, TOPKAT, Dragon, T.E.S.T., and ECOSAR. The present manuscript elaborates a detailed view on cosmetic preservatives, regulatory aspects and application of computational strategies for toxicity prediction.