This study aims to identify the factors that determine the intention to adopt cloud ERP by Tunisian small, medium, and micro-enterprises (SMEs). Based on previous studies on cloud computing and cloud ERP, a research model was developed. A questionnaire survey was administrated online with two samples of adopters and non-adopters of traditional ERP during the first wave of the COVID-19 pandemic in Tunisia. Collected data were analyzed through PLS-SEM techniques. Findings suggest that both compatibility and technological readiness are favoring the cloud ERP adoption by SMEs adopters of traditional ERP, whereas compatibility and managers' support are driving its adoption by SMEs, non-adopters of these systems. Relative advantage, complexity, data security and confidentiality, financial readiness, regulatory support, and competitive pressure are insignificant factors for the two samples. This research contributes to fill some of the highlighted theoretical gaps in the field and may help managers and ICT staff in SMEs, cloud ERP providers, and policy makers to make more informed decisions.